Drug Standards
Apexbio Technology LLC Salmeterol xinafoate 94749-08-3 10mM (in 1mL DMSO)
Salmeterol xinafoate (CAS 94749-08-3) is a long-acting 2-adrenergic receptor agonist that induces smooth muscle relaxation leading to bronchodilation and vasodilation In vitro studies show that salmeterol reduces retinal M ller cell death by inhibiting IRS-1 (Ser307) phosphorylation implicating -adrenergic signaling in cell survival pathways In vivo experiments demonstrate that salmeterol suppresses pro-inflammatory cytokine production in allergen-stimulated murine models and attenuates inflammatory responses via modulation of dendritic cells Clinically salmeterol has been shown to enhance peak expiratory flow in asthma and is studied in combination therapies for persistent asthma supporting its utility in respiratory and immunological research
Selleck Chemical LLC Rucaparib (AG-014699) phosphate 10mM/1mL 459868-92-9 PF-01367338
Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
![Medchemexpress LLC Pyridine, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-2-nitro- | 877397-70-1 | 99.9% | C13H9Cl2FN2O3 | 1 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC Pyridine, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-2-nitro- | 877397-70-1 | 99.9% | C13H9Cl2FN2O3 | 1 G
This product is Crizotinib impurity 1, also known as Pyridine, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-2-nitro-. It features a high purity of 99.94% as determined by HPLC.
- High purity (99.94% HPLC)
- Powder storage conditions: -20°C for 3 years or 4°C for 2 years
- In solvent storage conditions: -80°C for 6 months or -20°C for 1 month
- Appearance: Off-white to light yellow solid
Apexbio Technology LLC Larotrectinib 1223403-58-4 5mg
Larotrectinib (CAS 1223403-58-4) is a selective orally bioavailable inhibitor of tropomyosin receptor kinases (Trk) which are receptor tyrosine kinases implicated in oncogenic signaling upon neurotrophin activation By binding to Trk proteins larotrectinib disrupts neurotrophin-mediated phosphorylation and downstream signaling leading to growth inhibition and induction of apoptosis in tumor models with Trk gene fusions or overexpression It has gained regulatory approval for use in the study and treatment of solid tumors harboring Trk alterations supporting its application in preclinical and clinical oncology research focused on Trk-driven malignancies
Medchemexpress LLC Decitabine | 2353-33-5 | 99.9% | C8H12N4O4 | 2 G
Decitabine is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. It incorporates into DNA in place of cytosine, which can covalently trap DNA methyltransferase to DNA, leading to irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis, demonstrating potent anticancer activity.
- Deoxycytidine analogue antimetabolite
- DNA methyltransferase inhibitor
- Induces cell G2/M arrest
- Induces cell apoptosis
- Exhibits potent anticancer activity
Medchemexpress LLC Capecitabine (Standard) | 154361-50-9 | 99.99% | C15H22FN3O6 | 100 MG
Capecitabine (Standard) is the analytical standard of Capecitabine, an oral proagent. It is designed for research and analytical applications.
- Capecitabine is converted to its active metabolite, 5-FU, by thymidine phosphorylase.
- It is commonly used in qualitative, quantitative, and methodological research experiments, including HPLC, GC, and MS.
- The product appears as a solid, with a color ranging from white to off-white.
- Molecular Weight: 359.35.
- Shipping: Room temperature in continental US; may vary elsewhere.
- Storage: Please store the product under the recommended conditions specified in the Certificate of Analysis (COA).
Selleck Chemical LLC ARQ 621
ARQ 621 is an allosteric and selective Eg5 mitotic motor protein inhibitor Phase 1
Apexbio Technology LLC Indapamide 26807-65-8 10mM (in 1mL DMSO)
Indapamide (CAS 26807-65-8) is a sulphonamide-derived diuretic structurally distinct from thiazides It functions by inhibiting sodium reabsorption primarily at the distal convoluted tubules of the nephron resulting in increased excretion of sodium and water This action reduces plasma volume and peripheral vascular resistance contributing to its antihypertensive effects Indapamide is also studied for its utility in models of decompensated cardiac failure due to its natriuretic and vasodilatory properties making it relevant for research into cardiovascular disease and fluid balance regulation
Apexbio Technology LLC Acebutolol HCl 34381-68-5 1g
Acebutolol hydrochloride (CAS 34381-68-5) is a selective 1-adrenergic receptor antagonist By competitively inhibiting the binding of catecholamines to 1-adrenergic receptors acebutolol modulates sympathetic nervous system activity resulting in decreased heart rate and myocardial contractility This pharmacological profile underlies its utility in preclinical studies on cardiovascular regulation including models of hypertension angina pectoris and cardiac arrhythmias Acebutolol HCl is widely used in biomedical research to investigate -adrenergic signaling pathways and to evaluate therapeutic approaches targeting cardiac function and blood pressure control
Apexbio Technology LLC Digoxin 10mM (in 1mL DMSO)
B7684 is a small molecule currently investigated in biomedical research for its modulatory effects on cellular signaling pathways It is reported to interact with specific protein targets involved in regulatory mechanisms thereby influencing downstream biological processes relevant to disease models B7684 serves as a chemical tool to probe pathway modulation and target validation in cellular and molecular biology studies Its applications include elucidating target-specific mechanisms and supporting preclinical research into therapeutic strategies
Apexbio Technology LLC Granisetron HCl 107007-99-8 100mg
Granisetron HCl (CAS 107007-99-8) is a selective antagonist of the serotonin 5-hydroxytryptamine type 3 (5-HT sub 3 /sub ) receptor By competitively inhibiting 5-HT sub 3 /sub receptor-mediated signaling Granisetron HCl suppresses serotonin-induced activation of the vomiting reflex pathway in both central and peripheral nervous systems This pharmacological activity underlies its utility in preventing and investigating the mechanisms of chemotherapy-induced and postoperative nausea and vomiting Granisetron HCl is widely employed in preclinical and clinical studies to elucidate 5-HT sub 3 /sub receptor function and to explore antiemetic strategies
Medchemexpress LLC Trimethyl chitosan (N,N,N-Trimethylchitosan) | 52349-26-5 | 50 MG
Trimethyl chitosan (N,N,N-Trimethylchitosan) | 52349-26-5 | 50 MG
Apexbio Technology LLC H1 histamine receptor antagonist. Clemizole hydrochloride 5mg. 728865-23-4. MFCD22665727
H1 histamine receptor antagonist. Clemizole hydrochloride 5mg. 728865-23-4. MFCD22665727
Medchemexpress LLC Impurity of Doxercalciferol | 127516-23-8 | C28H44O2 | 5 MG
Impurity of Doxercalciferol is an impurity of doxercalciferol, a synthetic analog of ergocalciferol (vitamin D2). It is used as an agent for secondary hyperparathyroidism and metabolic bone disease, and it suppresses parathyroid synthesis and secretion.
- Used as an agent for secondary hyperparathyroidism
- Used as an agent for metabolic bone disease
- Suppresses parathyroid synthesis and secretion
- Synthetic analog of ergocalciferol (vitamin D2)
- Store at 4°C, protect from light, and under nitrogen